Most children with Tourette syndrome (TS) experience a marked decline in the severity of tic symptoms during adolescence.
Future research controlling for childhood traumatic experiences may contribute to explaining brain morphology in people with psychosis.Ĭaudate volumes in childhood predict symptom severity in adults with Tourette syndrome.īloch, Michael H Leckman, James F Zhu, Hongtu Peterson, Bradley S The findings indicate that childhood trauma is associated with neuroanatomical measures in FEP. The experience of childhood trauma was a significant predictor of right and total amygdalar volumes and the hippocampal/amygdalar complex volume as a whole. There was no significant association between predictor variables and right hippocampal volume. The experience of childhood trauma was a significant predictor of left hippocampal volume, although age at FEP also significantly contributed to this model. There was a high prevalence of lifetime (95%) and childhood (76%) trauma in the sample. Potential confounding variables (age at FEP and delay to scan from recruitment) were selected a priori for inclusion in multiple regression analyses. Data were subject to correlation analyses (r and r (pb)). Twenty-one individuals, who had previously undergone magnetic resonance imaging procedures as part of the longitudinal Northern Ireland First-Episode Psychosis Study, completed measures assessing traumatic experiences and were included in the analysis. The study employed an observational retrospective design. This study aimed to explore the association between the experience of childhood trauma and hippocampal and amygdalar volumes in a first-episode psychosis (FEP) population. However, the relationship between childhood trauma and such abnormalities in psychosis has not been investigated. Similar neuroanatomical abnormalities are observed in people who have been exposed to childhood trauma and people with psychosis. Hoy, Katrina Barrett, Suzanne Shannon, Ciaran Campbell, Clodagh Watson, David Rushe, Teresa Shevlin, Mark Bai, Feng Cooper, Stephen Mulholland, CiaranĪ history of childhood trauma is common in individuals who later develop psychosis.
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